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ABSTRACT Background: Gastro Esophageal Reflux Disease is a condition that occurs when the refluxed stomach contents lead to troublesome symptoms and/or complications. Most of patients with chronic gastro-esophageal reflux disease develop Erosive Esophagitis (EE). Healing of EE, resolution of symptoms and prevention of complications are the treatment goals. The management of GERD is done by gastric acid suppressive therapy with a proton pump inhibitor (PPI). Here, Pantoprazole and Esomeprazole are used since it provides better efficacy than other PPIs. Aim: To compare the effectiveness of Pantoprazole versus Esomeprazole and to assess the medication adherence in erosive gastro-esophageal reflux disease patients. Materials and Methods: The prospective observational comparative study was carried out in 56 patients with GERD. The study was conducted by categorising them into two groups, 28 patients taking Pantoprazole and 28 patients taking Esomeprazole. Initially, Pantoprazole or Esomeprazole were given twice daily for both the groups respectively for two weeks followed by once daily for six weeks. The grading of Reflux Esophagitis is based on the Los Angeles(LA) classification. Symptom severity is assessed by using FSSG Scale. Patient's medication adherence will be assessed by using Adherence to Refill and Medication Scale (ARMS). Patient's quality of life will be measured using GERD-HRQL questionnaire. Result: By using those scales, there shows mild differences between the two groups in the healing rate of reflux esophagitis. The LA grade on comparsion of both the groups, the severity of Esomeprazole group is rapidly decreased compared with Pantoprazole group. Esomeprazole 40mg provided significantly greater healing than Pantoprazole 40mg after 8 weeks of treatment in patients with EE. Conclusion: Esomeprazole is more effective than Pantoprazole for rapid relief of heartburn symptoms and acid reflux symptoms in patients with reflux esophagitis.