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Basic life support (BLS) is the foundation for saving lives after cardiac arrest. Basic life support (BLS) with cardiopulmonary resuscitation (CPR) provided at the right time greatly improves survival following cardiac arrest.. The aim of the study was to assess the impact of simulation based training programme on knowledge and practice regarding basic life support among undergraduate nursing students at nursing college Indore, M.P. Methods and material : A quantitative research approach with a pre-experimental one-group pre-test and post-test design was used for the study. The setting of the study was Index nursing college Indore Madhya Pradesh. By using the non-probability purposive sampling technique 60 undergraduate nursing students were selected. A self-structured questionnaire was used to assess the demographic data and knowledge and practice was observed by checklist regarding basic life support which was prepared based on American Heart Association Guidelines for BLS. Result: In the pretest, 35 (58.3%) participants had obtained poor knowledge grade; 20 (33.3%) had obtained average knowledge grade; 5(8.3%) had obtained good knowledge grade; and non of the participant had obtained excellent knowledge grade. In the posttest, none of the participants had obtained poor knowledge grade; 8 (13.3%) had obtained average knowledge grade; 25(41.6%) had obtained good knowledge grade; and 27 (45%) had obtained excellent knowledge grade. The intervention was helpful in improving the knowledge grade of the participants. In the pretest, 33 (55%) participants had obtained Inadequate practice score; 22 (36.66%) had obtained moderately adequate; and 5(8.33%) participant had obtained adequate score. In the posttest, none of the participants had obtained inadequate score; 12(20%) had obtained moderately adequate score; and 48 (80%) had obtained adequate score. The intervention was helpful in improving the practical skill of the participants. The statistically significant association was found between area of maximum experience, previous experience on BLS and the pretest knowledge grades (P>0.05). The statistically significant association was found between area of maximum experience, previous experience on BLS and the pretest knowledge grades (P>0.05).