Published Paper Details:

Transdermal drug delivery has made an important contribution to medical practice, but it has yet to fully achieve its potential as an alternative to the oral delivery and hypodermic injections. An advantage of a transdermal drug delivery route over other types of delivery systems such as oral, topical, intravenous, intramuscular, etc. is that the patch may essentially can provide a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The purpose of this investigation is to investigate the physicochemical evaluation and anti-microbial activity of plant extract of leucas aspera root by using methanol and ethyl acetate in 1:1 ratio. The primary phytochemical analysis of root extract of leucas aspera showed the presence of alkaloids, glycosides, tannins, flavonoids, terpenoids, saponins. Six batches of H1, H2, H3, S4, S5& S6 Plant extract (root) of Leucas aspera Transdermal patches were prepared by solvent casting technique. From the results of invitro diffusion and physicochemical studies, H2 & S5 was concluded as best formulation. Then they were subjected to screening of anti- microbial activity The anti-microbial screening result showed that the H2 was highly inhibiting the microbial growth around the patch and additional research on these plants could lead to the discovery of novel bioactive chemicals.