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The methanol excerpt from the leaves of Heliotropium indicum was tested for anthelmintic, analgesic, and neuropharmacological activities.Anthelmintic activities was assessed using earthworms and Trichuris spp.Various crude excerpt from Heliotropium indicum(basic, neutral and acidic compounds) at 10 mg/ mL, 50 mg/ mL, 10 mg/ mL and 150 mg/ mL were used to estimate the anthelmintic effect on Trichuris spp.Phytochemical analysis identified alkaloids, saponins, tannins, and reducing sugar. The plant also showed moderate analgesic activity. Neuropharmacological tests on Swiss albino mice demonstrated the excerpt's efficacity. Overall, the study suggests that Heliotropium indicum leaves could be a cost-effective treatment for Trichurisspp. Heliotropium indicum, a extensively used medicinal plant in traditional practices, has been reported to possess various pharmacological properties.This study aimed to research the antimicrobial activity of Heliotropium indicum excerpts against a range of bacterial and fungal strains. Aqueous and ethanolic excerpts of Heliotropium indicum leaves were prepared using standard extraction methods. The phytochemical composition of the excerpts was anatomized, and antimicrobial assays were conducted against selected bacterial strains (including both Gram-positive and Gram-negative bacteria) and fungal species. The minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) were determined.The study also included a comparative analysis of the antimicrobial efficacity of Heliotropium indicum excerpts with standard antimicrobial agents.