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Paper Title
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ALBENDAZOLE AND LEVAMISOLE COMBINED PHARMACEUTICAL FORMULATION BY USING REVERSE PHASE - HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors
Duggirala Mahendra, P MAMATHA, P SIRISHA, R RAMAKRISHNA, K ROSEMARY
Keywords
CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION
Abstract
In the present investigation, a simple, sensitive, precise and accurate RP-
HPLC method was developed for the quantitative estimation of Albendazole and Levamisole in bulk drug and pharmaceutical dosage forms.Albendazole was found to be soluble in dimethyl sulfoxide, strong acids, and strong bases. It is slig htly soluble in methanol, chloroform, ethyl acetate, and Acetonitrile. Albendazole is practically in soluble in water. Levamisole was found to be freely soluble in water; soluble in ethanol (~750 g/L), soluble in methanol and propylene glycol, slightly soluble in chloroform.Methanol: TEA Bufferl(pH-3.8) (30:70v/v) was chosen as the mobile phase. The solvent system used in this method was economical.The %RSD values were within 2 and the method was found to be precise.
The results expressed in Tables for RP-HPLC method was promising. TheRP-HPLC method is more sensitive, accurate and precise compared to the Spectrometer methods.This method can be used for the routine determination of Albendazole and Levamisole in bulk drug and Pharmaceutical dosage forms.
IJCRT's Publication Details
Unique Identification Number - IJCRT2404080
Paper ID - 254865
Page Number(s) - a684-a708
Pubished in - Volume 12 | Issue 4 | April 2024
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Duggirala Mahendra, P MAMATHA, P SIRISHA, R RAMAKRISHNA, K ROSEMARY, "METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ALBENDAZOLE AND LEVAMISOLE COMBINED PHARMACEUTICAL FORMULATION BY USING REVERSE PHASE - HIGH PERFORMANCE LIQUID CHROMATOGRAPHY", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.12, Issue 4, pp.a684-a708, April 2024, Available at :http://www.ijcrt.org/papers/IJCRT2404080.pdf
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Volume 14 | Issue 3
Last Date :
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Submit Manuscript Online Impact Factor: 7.97 Review Results : Within 02-03 Days Paper Publication : Within 02-03 Days
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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