Published Paper Details:

The strong sulfonylurea derivative glimepiride has become well-known as an efficient oral antidiabetic medication for the treatment of type 2 diabetes mellitus. Glimepiride synthesis aids in the development of scalable and effective industrial production procedures, in addition to advancing our knowledge of its chemical structure. The importance of glimepiride in the treatment of diabetes emphasizes the need for more research to optimize its synthesis for a wider range of therapeutic uses. In order to create the intermediate sulphonamide, 3-ethyl-4-methyl-1H-pyrrol-2(5H)-one carbamate must first be prepared. This is followed by a reaction with 4-(2-amino-ethyl) benzene sulphonamide. Glimepiride and a novel purification method for rans-4-methyl cyclohexylamine HC1 and 4-[2-(3-Ethyl-4-methyl-2-carbony1 pyrrolidine amido) ethyl]benzene sulphonamide, which were utilized in the synthesis of glimepiride, were produced by this sulphonamide when it reacted with phenyl (trans-4-methylcyclohexyl)carbamate. Glimepiride is quickly absorbed when taken orally, and its strong ability to bind proteins affects where it ends up in the body. Glimepiride's broad hepatic metabolism, mainly through cytochrome P450 enzymes, offers a number of advantages over sulfonylurea therapy, which is now widely and effectively used for NIDDM patients. These advantages could make glimepiride a potentially significant advancement in therapy.