Published Paper Details:

Drugs are natural or synthetic organic compounds which affects and improving functioning of living body system. They are used in the diagnosis, mitigation, treatment, diseases prevention and relief of discomfort. Decarbazine drug is a chemotherapy medication used in the treatment of melanoma liver cancer, carcinoma of pancreas etc. The discovery and development of the anti-tumor compound cis-platin and its derivatives play an important role in field of medicinal coordination chemistry. Therefore, the biochemical, pharmacological and medicinal studies of drug-metal complexes are very important. Looking at the wide applicability of metal-drug complexes the present work has been designed to thorough study of drug complexes of life essential metals with an anti-cancer drug Decarbazine. The electro analysis of the complex has been done using Polarographic and Amperometric methods and IR spectroscopy for the determination of physicochemical parameters. The probable formula for the complex has been worked out to be 1: 1(metal: drug). Microbial study has been done for knowing it's toxicity against various bacteria and fungi i.e. Staphylococcus aureus, Bacillus pumilus, Proteus mirabillis and Escherichia coli. Raper"s paper disk method has been used for determination of antimicrobial activities. Pharmacological activities i.e. in-vitro and in-vivo studies have been done for its possible therapeutic use. Mouse sarcoma cell line 180 and Balb/C mice were used for the anticancer screening of solid complex in-vitro and in-vivo respectively.