Published Paper Details:

The main objective of the present study was to develop floating sustained release formulation containing 600 mg of Pregabalin for once daily therapy by using polymers like HPMC K100M, Sodium CMC, PEO. Gastroretentive Drug Delivery System improves the bioavailability and therapeutic efficiency of drug. In the preformulation FTIR study was carried out for pure drug (Pregabalin), Pregabalin and excipients. It has not shown any interaction. The prepared floating sustained release tablets were evaluated for various parameters like thickness, weight variation, hardness, friability and drug content uniformity. The formulated sustained release matrix tablets were then evaluated for various physical characteristics like thickness, weight variation, hardness, friability, drug content. Compared to all formulations F6 showed the best buoyancy lag time, the buoyancy lag time for F6 was foud to be 50Sec.Total floating time of all formulations was found to be >12 hours. The formulation containing HPMC K 100M shows the higher swelling compared to that of the formulations containing PEO, Sodium CMC