Published Paper Details:

One of the most popular drug delivery methods is oral since it is less expensive, simpler to administer, and results in improved patient compliance. This delivery system's primary issue is incorrect medication absorption, which results in subpar efficacy. The drug's lower bioavailability is caused by its limited therapeutic absorption window, which prevents it from being absorbed at the absorption site for long enough. Intimate contact between the drug delivery system and the absorbing stomach mucosal membrane is provided by gastroretentive drug delivery systems, which enhances the therapeutic effectiveness of the drug and can extend the time between doses. The goal of the current work study was to create gastroretentive mucoadhesive amoxicillin microspheres using the spray drying method. These microspheres adhere to the gastric mucosa and release the medication over a longer period of time, reducing fluctuations in drug concentration and requiring lower doses and less frequent dosing. It can be said that Box-Behnken design was successfully used in the creation and improvement of mucoadhesive microspheres of amoxicillin. The carbopol 971P, HPMC K15M, and spray drying techniques were used to create the gastroretentive mucoadhesive microspheres of amoxicillin that can be administered in sachet packaging. With mucoadhesion of 82% up to 6 hours, the mucoadhesive microspheres created in the present investigations demonstrated consistent drug release over 8 hours.