Published Paper Details:

Cancer is the second leading cause of death worldwide and its treatment still represents a major challenge as cases continue to increase. Since the earliest medical records were kept, cancer as a disease has been described in the history of medicine. "Edwin Smith" and "George Ebers" papyri, contain descriptions of cancer written around 1600 B.C. Neoplasia (neo = new, plasia = tissue or cells) or neoplasm literally means new tissue in Greek. Lipid based nanoparticles provide the prospect of developing novel treatments owing to their unique size related characteristics. The process of integrating medicines into nanomedicines provides a novel drug discovery concept that might be used for therapeutic targeting. LBNPs advantages include high temporal and thermal stability, high loading capacity, ease of preparation, low production costs, and large-scale industrial production since they can be prepared from natural sources. LNPs(Lipid nanoparticles) are legitimate particulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical compounds which overall functionality to resolve biological barriers (biobarriers), allowing LNPs to selectively collect somewhere outside of disease-target cells again for responsive therapeutics. Most pharmaceutically important compounds were insoluble throughout water solutions, were chemical & physiologically unstable, or have toxicities. Moreover, the association of chemotherapeutic agents with lipid nanoparticles reduces active therapeutic dose and toxicity, decreases drug resistance and increases drug levels in tumor tissue by decreasing them in healthy tissue. LBNPs have been extensively assayed in in vitro cancer therapy but also in vivo, with promising results in some clinical trials. LBNPs were widely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in certain clinical trials. This study provides an overview of the many types of LBNPs which have been created in latest years and their applications and contributions in different types of cancers