Published Paper Details:

Administration of drugs through skin received great attention through the last decade. Transdermal drug delivery systems are dosage forms designed to deliver a therapeutically effective amount of drug across a patient's skin. Hence this study aims to formulate an anti-inflammatory transdermal patch using different polymers such as ethyl cellulose, hydroxy propyl methylcellulose with plasticizers poly-ethyl glycol 400. Patches were prepared through solvent casting method. The backing membrane was a non-permeable aluminium foil laminated and evaluated for thickness, physical appearance, folding endurance, moisture content, moisture uptake, weight uniformity, drug content determination, skin irritation studies. Drug content uniformity effects on inflammation and in-vitro release study, patches exhibited controlled release over more than 2 hrs. It was concluded from the research that, a herbal extract of the plant with HPMC showed moderate anti-inflammatory action and controlled drug release, thus can be selected for the development of transdermal patches for effective uses. The moisture content of batch B1 was measured and found to be 3.70%. The drug content of batch B1 was measured and found to be 84.79%.