Published Paper Details:

Abstract The main objective of the present study was to formulate and evaluate Ivabradine mucoadhesive buccal tablets by direct compression technique. Ivabradine is a novel medication used for the symptomatic management of stable angina pectoris and it has short half -life (2 hrs) with a bioavailability of 40% orally.The drug identity was confirmed by UV spectroscopy. The polymers used to sustain the drug release are Guar gum, Xanthan gum, HPMC K4M and Carbopol 934 . The compatibility studies between the drug and the polymer were studied using the FTIR spectroscopy and were found to be compatible. Preformulation parameters like tapped density, bulk density, carr's index, Hausner's ratio, compressibility index, angle of repose are studied and the results were found to be within the limits. Using the above polymers formulations f1 to f12 were manufactured by direct compression technique and the tablets were evaluated for their thickness, hardness, friability, weight variation and content uniformity test. The in vitro drug release studies were performed in Phosphate buffer of pH6.8 using USP type-II dissolution apparatus. From the dissolution studies it was found that f2 formulation containing HPMC K4M was best since it release minimum amount of drug (9.8%) initially and maximum drug (99.6%) at the end of 8hrs.The f2 formulation was subjected to stability studies for about 3months as per ICH guidelines and found to be stable.