Published Paper Details:

The purpose of this research was to develop a novel gastroretentive drug delivery system based on controlled delivery of active agent. Granisetron is an indole derivative having the antiemetic activity. It's a selective serotonin receptor antagonist. Granisetron blocks the action of serotonin at 5HT3 receptors. It also results in Suppression of Chemotherapy-and radiotherapy-induced nausea and vomiting. The incorporation of swellable and natural polymer for binding action and also good water solublility with high molecular weight such as carbopol present it in the gastro retentive floating tablets, which are designed to provide the desired controlled and complete release of drug for prolonged period of time. Lactose was used as filler. Buoyancy was achieved by adding an effervescent mixture of sodium bicarbonate and anhydrous citric acid. Floating tablets were prepared by direct compression method. All the required evaluation parameters such as hardness, friability, drug content uniformity and swelling index were performed and found within the acceptance limit.