Published Paper Details:

Dental caries occurs as a result of the localised disintegration of the hard tissues of teeth, which is predominantly brought on by acids, due to the presence of bacteria in the biofilm (dental plaque) on the surface of teeth. Dental caries is the term for these "cavities". The disadvantages of commercially available liquid mouthwashes containing artificial active ingredients include tooth discolouration, a greater alcohol content, odd tastes, xerostomia, and stability issues. creating the oral hygiene solid preparation (US6428770B1) in the form of herbal effervescent mouthwash tablets (CN106619318A, US8728446B2) using Azadirachta indica and Curcumin, which have antimicrobial, antibacterial, antiplaque, and anti-inflammatory activities. To conduct the optimisation research for effervescent granules, a 33 factorial design was employed. A total of 27 early experimental batches with various ratios of citric acid, tartaric acid, and sodium bicarbonate were produced using the fusion procedure. Scanning electron microscopy was used to further examine the combination made up of curcumin and hydroxypropyl cyclodextrin. The manufactured tablets' pre- and post-compression characteristics were evaluated. An in vitro antibacterial study employing the Agar well diffusion technique was conducted on S. mutans. Each experimental batch of effervescent granules had its pH, effervescent duration, and CO2 content measured. The final tablet formulation was created using six more batches. The considerable pre-compression parameter findings showed excellent flow characteristics and post-compression parameters.