Published Paper Details:

The goal of this study was to create a famotidine floating medication delivery system. The floating microspheres can be created to boost famotidine's absorption and bioavailability by keeping the system in the stomach for a prolonged period of time. Floating microspheres carrying famotidine were produced using a variety of polymers, including ethyl cellulose and hydroxy propyl methyl cellulose, using the solvent diffusion-evaporation method. The microspheres featured smooth surfaces, free-flowing behaviour, and good packing. Ethyl cellulose microspheres, with a yield of up to 73.320.14%, contained the most medication. Scanning electron microscopy confirmed their hollow structures with diameters of 331.6 nm. Extended drug release was seen in the created microspheres, and 73.250.23 percent buoyancy was found. The generated batches were examined for % entrapment efficiency, flow characteristics, and yield investigations. The formulations underwent stability testing, and information on in-vitro release and release kinetics was fed into a number of dissolving models. The oral bioavailability, effectiveness, and patient compliance of famotidine floating microspheres were found to be improved by this good and practical strategy for sustained drug release over an extended period of time.