Published Paper Details:

Tradition has it that the Fabaceae herb Cassia tora L. can be used to cure psoriasis and other skin conditions. Three flavonoids--luteolin-7-O-glucopyranoside (1), quercetin-3-O-D-glucuronide (2), and formononetin-7-O-D-glucoside (3) isolated from the ethanol extract of C. tora leaves were examined for their ant psoriatic activity using a UV-B-induced photodermatitis model in order to evaluate this information. By comparing their retention times with those of established standards like luteolin, quercetin, and formononetin, the flavonoids found in the ethanol extract were also identified using HPLC. In the UV-induced photodermatitis model, histological examination of the section showed that the ethanol extract (400 mg/kg), isolated compound and standard group did not exhibit Munro's microabscess, elongated rete ridges, or dilated capillary loops. The isolated ethanolic extract Compared to a positive control, isolated compounds 1, 2, and 3 significantly reduced the relative thickness of the epidermis. In the HPLC analysis, three flavonoids--luteolin, quercetin, and formononetin--were identified by contrasting the retention durations of standard markers. Using an animal model, we came to the conclusion that the flavonoids in Cassia tora leaves exhibit potent antipsoriatic properties.(1)