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ABSTRACT BACKGROUND OF THE STUDY Coronavirus disease 2019 (Covid-19) is defined as illness caused by a novel coronavirus called severe acute respiratory syndrome. Coronavirus 2 ( SARS - Cov - 2; formerly called 2019- ncov), which has first identified amid on outbreak of respiratory illness causes in Wuhan city. On March 11, 2000, the WHO declared Covid-19 a global pandemic (David J Cennimo,MD, FAAP, FACP, FIDSA, AAHIVS,Associate Professor of Medicine and Pediatrics, Adult and Pediatric infectious diseases, Rufagus New Jessay Medical School). Globally, there is a record over 218 million cases of coronavirus disease 2019(Covid-19) with over 4 million deaths and 5 billion totally vaccinated as of the time the study. In India, a record of an estimate of 1 million cases and over 30000 deaths exist and number is still increasing (John Hopkin University Coronavirus Resource Centre,2011). Kerala reported its first case of covid -19 on January 27, 2020, a 20 year old female presented to Emergency department in General Hospital, Thrissur, Kerala, with a one day history of dry cough and sore throat . Kerala have recorded....cases with over....deaths at the time of the study .. OBJECTIVES o Assess the knowledge of staff nurses regarding Covid-19 pandemic. o Assess the level of anxiety among staff nurses regarding Covid-19 pandemic. o Find out the association of knowledge among staff nurses regarding Covid-19 pandemic and selected demographic variables. o Find out the association of anxiety among staff nurses regarding Covid-19 pandemic and selected demographic variables. HYPOTHESIS o H1 :There will be significant association between level of knowledge with selected demographic variables. o H2 : There will be significant association between level of anxiety with selected demographic variables. METHODOLOGY The research design is used for this present study is non-experimental descriptive research design. The tools used for the study was a structured knowledge questionnaire to assess the level of knowledge regarding Covid-19 among staff nurses and a standardized scale (Generalized Anxiety Disorder Scale,GAD-7) is used to assess the level of anxiety among staff nurses towards Covid-19. The study was conducted by two days on 17th&21st December of 2021. Study conducted among staff nurses in PKDIMS, Vaniyamkulam, Ottapalam ,Palakkad District. Non-probability convenient sampling technique is used for the study. Total samples: 60. and 10 pilot study samples. RESULTS The mean value of level of knowledge was 6.65 (47%) and standard deviation is 2.13. The mean value of anxiety is 3.35 and standard deviation is 9.95. INTERPRETATION AND CONCLUSION The findings of study would help the staff nurses to develop some more knowledge and reducing the level of anxiety regarding Covid-19 and its various aspects.