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Paper Title
Synthesis, Characterisation and biological evaluation of Dihydropyrimidone derivatives employing a Novel Nickel based organometallic reagent as a catalyst under solvent free condition
Authors
B. B. Bahule, R.R. Sangpal, Shubhangi Dorage
Keywords
Biginelli reaction, Nickel based reagent, dihydropyrimidone derivatives
Abstract
Pyrimidones constitute a class of heterocyclic compounds with multifold applications in various fields of chemistry and medicine. The pharmaceutically important scaffold, has been synthesised by different researchers over a century of a work all over the world. Variety of chemical reagents and conditions have been used in this regard but prominently the Lewis acids are normally employed. In the present paper, we would like to report herein the green method for synthesising the dihydropyrimidone derivatives, commencing from the aromatic aldehydes, ethyl acetoacetate and urea under the catalysis of a novel nickel based organometallic reagent without employing any organic solvent for the conduct of a reaction . The work up is easy and the product formation takes place in very high yield. The products are characterised by IR and 1 H NMR spectroscopic spectral data.
IJCRT's Publication Details
Unique Identification Number - IJCRT2304842
Paper ID - 235175
Page Number(s) - g623-g627
Pubished in - Volume 11 | Issue 4 | April 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
B. B. Bahule, R.R. Sangpal, Shubhangi Dorage, "Synthesis, Characterisation and biological evaluation of Dihydropyrimidone derivatives employing a Novel Nickel based organometallic reagent as a catalyst under solvent free condition", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 4, pp.g623-g627, April 2023, Available at :http://www.ijcrt.org/papers/IJCRT2304842.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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