Published Paper Details:

The main limitation of dermal drug delivery is the poor penetration of APIs and other actives into the skin and scalp. The main barrier of the skin is located within its uppermost layer, the stratum corneum (SC). Several approaches have been developed to weaken this skin barrier. One of the approaches for increasing the skin penetration of drugs and many cosmetic chemicals is the use of vesicular systems, such as, increasing penetration enhancers, solvent system and liposomes. The invention, a dermal delivery technology, relates to penetration-enhancing pharmaceutical compositions comprising a novel combination of acrylic polymer complex with cetylated esters, emulsifiers, stabilizers, cetyl or stearyl alcohols and polar solvents, which, under appropriate conditions, combine into amphiphilic nanoparticles within a stabilized liquid dispersion for use in delivery of APIs and other cosmetic actives through the skin and scalp. The term TriPomer is used to describe these matrixes in order to differentiate them from other nanoparticles, such as ethosome, niosomes, cerasomes, dendrimers, liposomes, lipoids, solid lipid nanoparticles and other particles. The unique matrix with both ionic and non-ionic points of attraction, incorporate and concentrate a variety of different active agents and demonstrate stable properties with similarities to colloidal molecular structures. The compositions enhance topical transdermal fluxes of actives without permanently disrupting natural skin barrier function.