Published Paper Details:

An essential step in the drug discovery process is the development of analytical methods and subsequent technique validation. Despite the drug's good potency, the lack of a recognised analytical method prevents the drug from being sold. This is to guarantee the standard and the drug's safety. The main goal of this review is to provide information on the traditional and cutting-edge methods used to analyse drugs in both their unprocessed and processed forms, as well as to examine the stability of the drugs in the presence of excipients and other stressors that may occur during the course of their shelf life. The review paper sheds light on hyphenated techniques such LC-MS-MS, LC-NMR-MS, GC-MS, and LC -MS for the analysis and impurity profiling of medicines. The development of bioanalytical methods for the quantitative detection of pharmaceuticals in various biological matrices is also covered in this review. Additionally, it offers a way to assess the medications' biological safety via addressing the SIAMs (stability indicating assay methods).