Published Paper Details:

In the past two decades, colon-targeted drug delivery has become more significant due to its ability to deliver therapeutic proteins, peptides, and medicines for the treatment of numerous colonic disorders. Traditional methods for colon-targeted administration, including Prodrugs, pH, time-dependent, and microflora-triggered systems, have shown varying degrees of effectiveness in the past. The medicine must be shielded from absorption and/or the environment of the colon for effective colon-targeted drug delivery. Abruptly released into the colon after passing through the upper gastrointestinal tract. In To the various therapeutic demands, ongoing efforts have been made to build colon-targeted drug delivery systems with increased site specificity and adaptable drug release kinetics. Recent years have seen the development of several new systems for colon-targeted drug delivery, including pressure-dependent systems, microscopic sponges, pectin and galactomannan coating, microbially triggered osmotic systems, lectins and neoglyconjugated, among others. These systems are said to have better in-vivo site specificity and design rationale than earlier ones. This item of review provides a summary of different strategies for colonic-targeted drug administration.