Published Paper Details:

Ibuprofen is considered as the most important Non-steroidal anti-inflammatory drug and widely used for treatment of major and minor pain, arthritis etc. The present work has been done to formulate tablet of Ibuprofen, the drug having low aqueous solubility, by solid dispersion technique for enhancement of solubility. According to the biopharmaceutical classification system, BCS class II drugs are classified as drugs having low solubility and high permeability, therefore the barrier to their absorption is dissolution and solubility of the drug. Ibuprofen is BCS class II drug. According to our studies we found that, solid dispersion is the promising tool which can help to increase the solubility of the drug. As these drugs have low solubility and high permeability, increase in the solubility of such drugs can probably improve the onset of action of the drug. In our project we have selected a drug belonging from BCS class 2 that is Ibuprofen and tried to enhance the solubility by solid dispersion technique. As a result, we found that solubility of the drug before processing 24.6192 mcg/ml was found to be and the solubility of the same drug after processing 32.8394 mcg/ml was found to be of SD ratio 1:3 which shows that the solubility of the drug is enhanced by folds with the help of solid dispersion technique. In the present work, Solubility of pure drug was determined. Different solid dispersion ratios using mannitol as a carrier were prepared and their solubility was determined and compared with standard. The SD ratio having optimized solubility was selected for tablet formulation. The tablets were formulated by wet granulation method using Croscarmellose sodium as superdisintegrant. The tablets were evaluated for physical parameters, disintegration time, hardness, thickness, weight variation, friability, and in vitro drug release. All the physical parameters were in acceptable limit of pharmacopeial specification.