Published Paper Details:

Emulgel have emerged as one of the most interesting Topical delivery system as it has dual control release system i.e. gel and emulsion. Topical applications of drug offers many advantages for delivering drug directly to the site of action and deliver the drug for extended period of time at effected site. In the present study, an attempt has been made to formulate the topical drug delivery system of Pentoxifylline EP in the form of Emulgel. Pentoxifylline EP is widely used Non steroidal Anti-inflammatory drug, mostly used to relieve pain and also have significant results in the treatment of oral submucous fibrosis treatment. Emulgel batches were formulated and developed to get the optimized batch using 32 Factorial Design. For the formulation of emulgel, gelling agent Acrypol 934P and Penetration enhancer Menthol were selected as independent variables whereas Viscosity and in vitro drug release were the dependent variables. All the formulation developed were evaluated for the post formulation studies like color, phase separation, pH, rheological behaviour, spreadability, swelling index, drug content, In- vitro drug release and stability studies and all the results observed were within official limit