Published Paper Details:

Pediatric drug delivery systems require special consideration due to physiological, psychological, and developmental differences compared to adults. Conventional dosage forms such as tablets and capsules are often unsuitable for children due to swallowing difficulties, risk of choking, and poor acceptability. Liquid formulations, although commonly used, suffer from issues such as dosing inaccuracies, stability concerns, and unpleasant taste. The present research work focuses on the design and evaluation of a chewable oral jelly formulation containing Paracetamol, a widely used analgesic and antipyretic agent in pediatric therapy. The objective was to develop a palatable, stable, and effective dosage form that enhances patient compliance and ensures accurate dosing. The formulation was developed using hydrophilic polymers such as pectin, gelatin, and sodium alginate, along with sweeteners, flavoring agents, and preservatives. Various formulations were prepared by altering polymer concentrations and evaluated for physicochemical parameters including pH, viscosity, drug content uniformity, syneresis, texture, and in vitro drug release profile. The optimized formulation demonstrated desirable characteristics such as acceptable taste, uniform drug distribution, minimal syneresis, and rapid drug release. Stability studies conducted as per ICH guidelines confirmed the formulation's stability. The study concludes that chewable oral jelly is a promising and patient-friendly alternative to conventional pediatric dosage forms.