Published Paper Details:

Costus igneus, also referred to as the "Insulin Plant," is a tropical medicinal plant with proven antidiabetic activity and common use in traditional treatment of metabolic disorders.This research sought to investigate the phytochemical composition, total phenolic content, and pharmacokinetic characteristics of Costus igneus leaf extracts that were procured using methanolic, aqueous, and hydroalcoholic extraction procedures. Initial screening showed the occurrence of major bioactive compounds like flavonoids, alkaloids, terpenoids, saponins, phenolics, and glycosides, which have been reported to be responsible for the drug effects of the plant. Total phenolic content quantification showed the high occurrence of antioxidant components, indicating good therapeutic potential. Also, in silico analysis with SwissADME was utilized to assess pharmacokinetic properties of major phytoconstituents like quercetin, kaempferol, diosgenin, and corosolic acid. These compounds had desirable drug-likeness profiles, gastrointestinal absorption, and low cytochrome P450 inhibition, validating their potential as therapeutic compounds. The findings validate the historical claims of the antidiabetic, antioxidant, anti-inflammatory, hepatoprotective, and nephroprotective activities of Costus igneus. This research fills the gap between traditional use and scientific proof, providing information for further development of standardized herbal drugs and furthering the inclusion of Costus igneus in evidence-based phytomedicine.