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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)

International Peer Reviewed & Refereed Journals, Open Access Journal

IJCRT Peer-Reviewed (Refereed) Journal as Per New UGC Rules.

ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013

Call For Paper - Volume 14 | Issue 3 | Month- March 2026

Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 7.97 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(CrossRef DOI)

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  Published Paper Details:

  Paper Title

BIOANALYTICAL METHOD FOR HMG COA REDUCTASE ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS

  Authors

  Tozer Meena Sandela

  Keywords

RP-HPLC/UV, clinical pharmacokinetic, factorial design.

  Abstract


Here, a bio-analytical technique utilizing RP-HPLC/UV was created and thoroughly verified for the simultaneous measurement of candesartan and rosuvastatin in human and rat plasma using atorvastatin as an internal reference. The material was cleaned up using solid-phase extraction, and its later optimization was done to remove the matrix impact and increase extraction efficiency. Using Design Expert Software, a three-level factorial design was performed to optimize the composition of the mobile phase and evaluate the impact of the mobile phase's pH as part of a quality by design strategy. The new HPLC technique can be employed in an LC-MS/MS experiment and is mass compatible. The current work offers a useful technique for researching drug-drug interactions between statins and sartans; as a result, it can be applied to both clinical pharmacokinetic studies and therapeutic drug monitoring.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2103769

  Paper ID - 302585

  Page Number(s) - 6602-6609

  Pubished in - Volume 9 | Issue 3 | March 2021

  DOI (Digital Object Identifier) -   

  Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Cite this article

  Tozer Meena Sandela,   "BIOANALYTICAL METHOD FOR HMG COA REDUCTASE ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 3, pp.6602-6609, March 2021, Available at :http://www.ijcrt.org/papers/IJCRT2103769.pdf

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Call For Paper March 2026
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ISSN and 7.97 Impact Factor Details


ISSN
ISSN
ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
ISSN
ISSN and 7.97 Impact Factor Details


ISSN
ISSN
ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
ISSN
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