Published Paper Details:

The goal of this research was to determine the atheroprotective effect of Tecoma stans ethanolic flower extract (EETS) against intimate-media carotid artery thickness (cIMT) and malondialdehyde level (MDA) on rats exposed to cigarette smoke. Thirty adult Wistar rats in group K2, K3, and K4 (100 mg / kg b.w / day; 200 mg / kg b.w / day; and 400 mg / kg b.w / day) were divided into five groups and exposed to cigarette smoke, 3 pc cigarettes / day, respectively. In both participants the treatment period was 28 days. Blood was taken out of the heart to assess the amount of MDA. To assess cIMT, histological slide was obtained from carotid artery intima-media. The administration of EETS could substantially prevent the development of atherosclerosis due to oxidative stress by decreasing the MDA level (p<0.05) and decreasing the degree of changes in cIMT (p<0.05). The present study found that EETS could prevent the development of atherosclerosis due to smoke exposure by reducing the level of MDA, that is, the marker of oxidative stress associated with reduced changes in cIMT. Further researches on additional EETS bioactivity as an antioxidant are therefore required for the invention of potent atheroprotective drug.