Published Paper Details:

Irbesartan is an angiotensin II type, receptor antagonist. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation and renal reabsorption of sodium. Irbesartan blocks the vasoconstricting and aldosteron secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle. Irbesartan is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This drug works by blocking the hormone angiotensin thereby relaxing blood vessels, causing them to widen. It is also used to treat congestive heart failure and to help protect the kidneys from damage due to diabetes.