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Carica papaya is one of the most popular and economically important plants in the world as its fruit is a common grace. The papaya, papaw, or pawpaw is a tall herbaceous plant Carica papaya, with 22 species in the genus.Caricabelongs toCaricaceaefamily. The native of papaw is tropical region of America, mainly from southern Mexico to Central America. Juice of Papaya leaves was believed to oppose dengue. Its leaves are familiar for its anti-malarial properties by increasing the platelet count and are the best home remedy to fight against dengue fever and other illnesses. The therapeutic effect of aqueous extract of papaya (Carica papaya) leaves is assumed to contain several bioactive components such as papain, chymopapain, cystatin, L-tocopherol, ascorbic acid, flavonoids, cyanogenic glucosides and glucosinolates. These exhibit antioxidant property, anti-tumor activity and immune modulator effect which help in reducing lipid peroxidation. Many tropical and subtropical countries are submerged by dengue infection, caused by viruses belonging to Flaviviridae family. In despair, many people have resorted to use papaya leaf extract for effective in fighting against dengue fever. Specialists from the Indian Institute of Forest Management have recently conducted a study and reported to have a significant improvement in overall health and also reduce side effects for increased comfort. Besides,itpossesses some extraordinary anti-cancer property. With the recent dengue outbreak, the use of papaya leaves serves as a natural cure for dengue which received much interest among the population. There is no specific therapy for dengue even though the infection has a significant mortality. Due to its easy availability and affordability, the papaya leaves can be widely used as a natural medicine for curing Dengue.