Published Paper Details:

Oral cancer, especially squamous cell carcinoma has been a leading type of cancer in North-east India. The high abundance of this cancer type is due to the indiscriminate use of tobacco and smoking. However, to study the exact mechanism of carcinogenesis and its progression, one needs a large amount of sample to analyze from the subjects. This particularly become problematic as there is scarcity of adequate human sample and the whole genesis cannot be studied at first. To address this problem, scientists are now using a very potent oral cancer forming agent known as 4-Nitroquinoline-1-oxide(4NQO) to produce oral cancer in mice test systems in vivo and study the pathway from developing stages to ultimate cancer form and the time needed for complete tumorigenesis. So, it is critical to know the nature of this carcinogen and its usability and hence this review provides a comprehensive knowledge about this water-soluble carcinogen and its mode of action along with some potential utilitarian perspective.