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BACKGROUND: Healthcare-associated infections (HAIs) are one of the most serious threats to patient health and remain a major challenge for healthcare providers worldwide. Among HAIs, surgical site infections (SSIs) are one of the most commonly reported HAIs, and wound infections remain an important cause of morbidity and mortality, accounting for approximately one-fifth of all HAIs. With increasing in rate of SSIs that can be fatal for patient which can be prevented with proper guidance before and after surgery need to be emphasized as nurses plays an integral part. By assessing patient awareness and knowledge about the surgical site infection, deeper insights into existing patient perception and practices can be gained, thereby helping to identify attributes that influence the patients in adopting healthy practices and responsive behaviour. OBJECTIVES OF THE STUDY 1. To assess the level of Knowledge regarding Surgical Site Infection among Post-operative Patients in selected hospitals, Kamrup(M), Assam. 2. To assess the level of Self-care Practice regarding Surgical Site Infection among Post-operative Patients in selected hospitals, Kamrup(M), Assam. 3. To find out correlation between Knowledge and Self-care Practice regarding Surgical Site Infection among Post-operative Patients in selected hospitals, Kamrup (M), Assam. 4. To find out association between Knowledge regarding Surgical Site Infection among Post-operative patients in selected hospitals with selected demographic variables, Kamrup (M), Assam. 5. To find out association between Self-care Practice regarding Surgical Site Infection among Post-operative patients in selected hospitals with selected demographic variables, Kamrup (M), Assam. METHODS AND MATERIAL A descriptive research design was used in the study to accomplish the objectives. Non- probability purposive sampling technique was used for obtaining sample for the study. Study was undertaken on 70 samples in setting of selected hospitals of Kamrup (M), Assam. Respondents were selected on the basis of inclusive and exclusive criteria. Self-structured Knowledge questionnaire and inventory checklist on SSI was used as a tool to assess the level of knowledge and self-care practice. RESULT Out of 70 participants, majority i.e, 25(35.7%) belongs to the age group of 29-39 years, 21(30%) belongs to the age group 40-50 years, 14(20%) belongs to the age group of 51-60 years and only 10(14.3%) belongs to the age group 18-28 years among which 38(54.3%) were female and 32(45.7%) were male.37(52.9%) were graduate and above, 18(25.7%) were higher secondary education, 10(14.3%) have secondary education ,5(7.1%) have primary education. Majority i.e,24(34.3%) were govt. employee,19(27.1%)were homemaker, 9(12.9%) were self-employed/business, 7(10%) were private employee, 4(5.7%) were daily wager, 3(4.3%) were students, 2(2.9%) were unemployed and retired, respectively among which 19(27.1%) were earning between Rs 53,361- Rs 80,109 ,16(22.9%) were earning between Rs 80,110- Rs 1,06,849,12(17.1%) were earning between Rs 1,06,850 -Rs 2,13,813 ,9(12.9%) were earning between Rs2,13,814 and above ,8(11.4%) were earning between Rs 31,978 - Rs 53,360, 6(8.6%)were earning between Rs 10,703 - Rs 31,977.The participants underwent surgery i.e, 30 (42.9%) cholecystectomy,13(18.6%)appendectomy,11(15.7%)LSCS, 8(11.4%)exploratory laparotomy, 5(7.1%)hernia repair whereas 1 (1.4%)liver transplant, renal transplant and hysterectomy, respectively among which 32(45.7%) followed up between 11-20 days, 23(32.9%) followed up <=10 days, 10(14.3%) followed up between 21-30 days and 5(7.1%) followed up after >30 days. The study shows that 39(55.7%) had moderately adequate knowledge and 31(44.3%) had adequate knowledge regarding surgical site infection among post operative patients.55(78.6%) had adequate practice and 15(21.5%) had moderately adequate practice regarding surgical site infection among post operative patients. CONCLUSION The study concludes that when the knowledge regarding surgical site infection among post operative patients increases then their practice towards it also increases. There is a need to improvise more participation by health care workers in providing knowledge regarding Surgical Site Infection and Self-care Practice in order to prevent from SSI among post-operative patients.