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BACKGROUND: Needle stick injuries refer to puncture wounds or cuts caused by needles , scalpels,or other sharp objects contaminated with bodily fluids , such as blood , saliva , or other potentially infectious materials . Needle stick injuries pose a significant threat to the health and wellbeing of healthcare workers , including nurses , doctors and other medical professionals . A needle stick injury is the penetration of the skin by a needle or other sharp objects which has been in contact with blood, tissue or other body fluids before the exposure and it can cause blood -borne diseases such as Hepatitis B, Hepatitis C and even AIDS. OBJECTIVES OF THE STUDY: 1. To assess the level of Knowledge regarding Needle Stick Injury among Nursing students in selected colleges and schools of Kamrup, Assam. 2.To assess the level of Attitude regarding Needle Stick Injury among Nursing students in selected colleges and schools of Kamrup , Assam. 3.To find out correlation between Knowledge and Attitude regarding Needle Stick Injury among Nursing student in selected colleges and schools of Kamrup , Assam. 4.To find out association between Knowledge regarding Needle Stick Injury among Nursing student in selected colleges and schools of Kamrup , Assam with their selected socio-demographic variables. 5.To find out association between Attitude score regarding Needle Stick Injury among Nursing student in selected colleges and schools of Kamrup, Assam with their selected socio-demographic variables. METHODS AND MATERIALS Quantitative Descriptive research design was used in this study to accomplish the objectives. Non -probability Convenience sampling technique was used for obtaining the adequate sample for the study. Study was undertaken on 246 nursing students studying in 2nd year B.Sc Nursing and 2nd year GNM in selected colleges of Kamrup , Assam. Students were selected based on the inclusion criteria. Knowledge regarding Needle Stick Injuries among Nursing students were assessed by using Structured Knowledge Questionnaire consisting of 30 questions and Attitude regarding Needle Stick Injuries among Nursing students were assessed by using 5-point Likert scale consisting of 10 statements to the respondents . RESULTS Result showed that out of 246 nursing students , all of the nursing students 246(100%) were aged 18-23 years, 236(95.9%) were female, 10(4.1%) were male , 123(50%) were students of B.Sc nursing 2nd year, 123(50%) were GNM 2nd year students , 246(100%) heard about Needle Stick Injury , 246(100%) source of information about Needle Stick Injury was from teachers , 174(70.7%) had encountered Needle Stick Injury , 72(29.3%) had not encountered Needle Stick Injury . In assessing Knowledge it reveals that out of 246 respondents , majority i.e. 199(80.9%) had moderately adequate Knowledge, 30(12.2%) had inadequate Knowledge and 17(6.9%) had adequate Knowledge .The mean Knowledge score was 17.67 with standard deviation of 3.26. In assessing Attitude it reveals that out of 246 respondents , 134(54.5%) had moderately desirable Attitude , 35(14.2%) had undesirable Attitude , 77(31.35) had desirable Attitude . The mean Attitude score was 34.21 with standard deviation of 6.83 The calculated Karl Pearson's Correlation Coefficient value of r=0.418 shows a moderately positive correlation between Knowledge and Attitude which was found statistically significant at p<0.001 level which clearly infers that when the Knowledge regarding Needle Stick Injuries among the Nursing students increases or decreases then their Attitude towards it also increases or decreases The association was statistically tested by chi square test. The analysis depicted that among all the demographic variables, educational courses (?2=8.782, p=0.012) and have you ever encountered Needle Stick Injury (?2=30.265, p=0.0001) had statistically significant association with Knowledge regarding Needle Stick Injuries at p<0.05 level and Socio-demographic variables educational courses (?2=37.932, p=0.0001) and have you ever encountered needle stick injury (?2=22.024, p=0.0001) had statistically significant association with level of attitude regarding needle stick injuries at p<0.05 level . CONCLUSION From this study it was observed that the majority of Nursing students had moderately adequate knowledge and moderately desirable attitude regarding Needle Stick Injury which indicate that the Nursing students are to prone accidental exposure to blood borne pathogens and body fluids. Hence , the investigator concluded that the best way to reduce NSI is to impart Knowledge and awareness about it .