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FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY OF MESALAZINE (5-AMINOSALICYLIC ACID/ MESALAMINE) BY USE OF TIME DEPENDED APPROARCH
Authors
Aman Dayatar,Mukesh Makwana,Priyank Shiyal,Shivang gosai
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Keywords
Mesalazine, Time-dependent drug delivery, Colon-targeted tablets, Ethyl Cellulose, Pectin, Compression coating, Inflammatory bowel disease, Delayed release, Mucoadhesion test
Abstract
The present study focuses on the Formulation and evaluation of a mesalazine mucoadhesive and time-dependent colon-targeted drug delivery system for the effective management of inflammatory bowel diseases. The objective was to ensure minimal drug release in the stomach and small intestine while providing a controlled, targeted release in the colon. Various batch formulations were prepared using different ratios of mucoadhesive polymers such as pectin etc. and time-dependent polymers such as ethlycellusoe to achieve this Colon Targeted Drug Delivery system.The selection criteria emphasized achieving minimal drug release in the first 4-5 hours to bypass the stomach and small intestine and provide protection from upper GIT, followed by a significant release after 5-6 hours for precise colon targeting. Dissolution studies were conducted on nine batches to determine the release profile. Among the tested formulations, Batch 4,5,6 and 7 minimal release during the initial 5 hours and a gradual, sustained release thereafter. Batch B3, B6 and B9 showing a higher mucoadhesion profile. Batch 6 the optimal candidate for time-dependent colon-targeted delivery and as well as muchoadhesion, ensuring effective site-specific drug release. Batch 5 and Batch 7 also displayed acceptable release profiles, showing a proper lag phase with a gradual increase in drug release but have less muchoadhesion. However, Batch 6 stood out with a superior balance of controlled release and lag phase with high muchoadhesion, confirming its suitability for colon targeting. In contrast, Batches 1, 2, 3, 4, and 9 showed premature drug release within the first 3-4 hours, failing to meet the criteria for time-dependent delivery. Similarly, Batch 8 exhibited a higher initial release, making it unsuitable for effective colon targeting. The study concludes that Batch 6 is the best formulation for a mesalazine mucoadhesive and time-dependent colon-targeted drug delivery system, offering enhanced therapeutic efficacy and reduced systemic side effects in the treatment of colonic disorders. This optimized system leverages controlled release technology to address the limitations of conventional therapies.Further investigations, including in vivo studies, are recommended to validate the in vitro findings and confirm the clinical potential of this formulation. The promising results from this study the way for advanced, targeted drug delivery systems for chronic gastrointestinal diseases.
IJCRT's Publication Details
Unique Identification Number - IJCRT25A3308
Paper ID - 280964
Author type - Indian Author
Page Number(s) - l402-l417
Pubished in - Volume 13 | Issue 3 | March 2025
DOI (Digital Object Identifier) -
No Of Downloads - 65
Author Country - India, 364522, AMRELI , AMRELI , 364522, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
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Aman Dayatar,Mukesh Makwana,Priyank Shiyal,Shivang gosai, "FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY OF MESALAZINE (5-AMINOSALICYLIC ACID/ MESALAMINE) BY USE OF TIME DEPENDED APPROARCH", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.13, Issue 3, pp.l402-l417, March 2025, Available at :http://www.ijcrt.org/papers/IJCRT25A3308.pdf
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