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Published Paper Details:
Genetic Variations in the MMP-3 Gene: Unravelling SNP Associations with Osteoarthritis Susceptibility and Progression
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Manjusha Dharavath,Maneesha Rayudu,Sreedhar Bodiga,Tejkumar Bhukya,Amulya Palle, Vijaya Lakshmi Bodiga
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Keywords
Osteoarthritis (OA), Matrix Metalloproteinase (MMP-3) gene, Single Nucleotide Polymorphisms (SNPs), Bone Mineral Density (BMD)
Abstract
Osteoarthritis (OA) is a multifactorial degenerative joint disorder influenced by genetic and environmental factors, with bone mineral density (BMD) playing a critical role in disease susceptibility. This study comprehensively examines the impact of single nucleotide polymorphisms (SNPs) within the matrix metalloproteinase (MMP-3) gene on BMD risk scores and their association with OA. A comparative sequence analysis identified five SNP variations distinguishing healthy and diseased individuals, suggesting their potential role in modifying protein structure, extracellular matrix interactions, and OA pathogenesis. Logistic regression modelling demonstrated an inverse correlation between BMD risk scores and disease susceptibility, with individuals possessing higher BMD scores exhibiting significantly reduced risk. Quintile-based stratification further confirmed this trend, as individuals in the highest BMD quintile (Q5) demonstrated a 71% lower risk of developing OA compared to those in the lowest quintile (Q1). These findings reinforce the clinical significance of SNP profiling as a predictive tool for identifying at-risk individuals and implementing early intervention strategies. Genetic screening may enable risk stratification, guiding preventative measures such as lifestyle modifications, nutritional supplementation, and targeted physical therapy for individuals with lower BMD scores. Furthermore, elucidating the molecular mechanisms linking SNPs to BMD regulation may facilitate the development of gene-based therapies and pharmacological interventions tailored to mitigate disease progression. The results of this study underscore the necessity for precision medicine approaches in OA management, integrating genetic risk assessment with personalized therapeutic strategies. However, to establish causality and further refine risk models, future research should incorporate functional validation studies, large-scale genome-wide association studies (GWAS), and longitudinal cohort analyses. Such advancements will be instrumental in enhancing early disease prediction, optimizing treatment strategies, and improving clinical outcomes in OA patients.
IJCRT's Publication Details
Unique Identification Number - IJCRT2503470
Paper ID - 279114
Author type - Indian Author
Page Number(s) - e153-e161
Pubished in - Volume 13 | Issue 3 | March 2025
DOI (Digital Object Identifier) - http://doi.one/10.1729/Journal.44167
No Of Downloads - 186
Author Country - India, -, -, -, -, Science and Technology
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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Manjusha Dharavath,Maneesha Rayudu,Sreedhar Bodiga,Tejkumar Bhukya,Amulya Palle, Vijaya Lakshmi Bodiga, "Genetic Variations in the MMP-3 Gene: Unravelling SNP Associations with Osteoarthritis Susceptibility and Progression", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.13, Issue 3, pp.e153-e161, March 2025, Available at :http://www.ijcrt.org/papers/IJCRT2503470.pdf
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