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Authors
VARSHA BABAN DHAVALE,AKSHATA ANIL PATIL
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Keywords
Mouth dissolving films, scleroglucan, flurbiprofen. adverse effect on git system.
Abstract
Scleroglucan can be used film forming polymer, along with 2% carbomer it gives good result, 1-2% glycerol use as plastizer, which give thin, elegant, transperants films.
Flurbiprofen (FP) is a nonsteroidal anti-inflammatory agent indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. FP is extensively metabolized in the liver. Serious gastrointestinal toxicity, such as bleeding, ulceration, and perforation.
The formulated mouth dissolving films were evaluated for physical characteristics such as uniformity of weight, thickness, folding endurance, drug content uniformity, surface pH, percentage elongation, tensile strength, disintegration time, In-vitro drug release tests and stability study and this entire test gave satisfactory results. The FTIR and DSC studies revealed that no physicochemical interaction between excipients and drug. All formulations exhibited essentially similar release patterns. The stability studies of the optimized formula were carried as per ICH guidelines.
So in these cases formulation of mouth dissolving films of flurbiprofen avoid above adverse effect to git system,.
IJCRT's Publication Details
Unique Identification Number - IJCRT2502249
Paper ID - 276294
Author type - Indian Author
Page Number(s) - c114-c136
Pubished in - Volume 13 | Issue 2 | February 2025
DOI (Digital Object Identifier) -
No Of Downloads - 134
Author Country - India, 411039, PUNE, PUNE, 411039, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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VARSHA BABAN DHAVALE,AKSHATA ANIL PATIL, "Scleroglucan based drug delivery system", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.13, Issue 2, pp.c114-c136, February 2025, Available at :http://www.ijcrt.org/papers/IJCRT2502249.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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