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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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A Comprehensive Review of the Latest Developments in Nanocrystal Formulations and Their Impact on the Solubility and Bioavailability of Poorly Water-Soluble Drugs
Authors
Shweta Ugale,Sayali Rajole,Aarti Bhandare,Mrs. K.T. Vaditake
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Keywords
Nanocrystals, Solubility enhancement, Bioavailability, Poorly water-soluble drugs, Drug delivery systems
Abstract
The pharmaceutical industry faces a significant challenge with the formulation of poorly water-soluble drugs, which often exhibit low bioavailability. Nanocrystal technology has emerged as a promising solution to enhance the solubility and bioavailability of these drugs. Nanocrystals, which are nanoscale particles of pure drug substance, have unique properties that enable them to improve drug dissolution rates and absorption profiles significantly. This review provides a comprehensive overview of the latest advancements in nanocrystal formulations and their impact on the solubility and bioavailability of poorly water-soluble drugs. The primary objectives of this review are to elucidate the mechanisms by which nanocrystals enhance solubility and bioavailability, to examine the various production methods and stabilization techniques for nanocrystals, and to assess the clinical and commercial implications of these formulations. Additionally, this review aims to highlight the regulatory considerations and future directions for nanocrystal technology in pharmaceutical applications. Major findings from recent studies indicate that nanocrystals can dramatically increase the solubility of poorly water-soluble drugs through size reduction and increased surface area, which enhances the dissolution rate. Furthermore, the stabilization of nanocrystals using surfactants and polymers is crucial to maintaining their efficacy and preventing aggregation. Various production techniques, including high-pressure homogenization, milling, and precipitation, have been optimized to produce stable nanocrystals with consistent properties. Clinical studies have shown that nanocrystal formulations can significantly improve the bioavailability of drugs, leading to enhanced therapeutic efficacy and reduced dosage requirements. In conclusion, nanocrystal technology represents a transformative approach in the formulation of poorly water-soluble drugs. The ability of nanocrystals to enhance solubility and bioavailability has been well-documented, with numerous successful applications in drug delivery systems. Future research and development in this field are expected to focus on further optimizing production techniques, exploring new stabilizing agents, and expanding the range of drugs that can benefit from nanocrystal formulations. This review underscores the potential of nanocrystals to address critical challenges in drug formulation and highlights their growing importance in pharmaceutical research and development.
IJCRT's Publication Details
Unique Identification Number - IJCRT24A5686
Paper ID - 262616
Author type - Indian Author
Page Number(s) - o840-o859
Pubished in - Volume 12 | Issue 5 | May 2024
DOI (Digital Object Identifier) -
No Of Downloads - 9
Author Country - India, 422102, Chincholi, Chincholi, 422102, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
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Shweta Ugale,Sayali Rajole,Aarti Bhandare,Mrs. K.T. Vaditake, "A Comprehensive Review of the Latest Developments in Nanocrystal Formulations and Their Impact on the Solubility and Bioavailability of Poorly Water-Soluble Drugs", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.12, Issue 5, pp.o840-o859, May 2024, Available at :http://www.ijcrt.org/papers/IJCRT24A5686.pdf
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The International Journal of Creative Research Thoughts (IJCRT) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies.
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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