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ABSTRACT- INTRODUCTION Glasgow Coma Scale was first published in the year 1974 at the University of Glasgow by Neurosurgery Professors Graham Teasdale and Bryan Jennett. The Glasgow Coma Scale (GCS) is being used to objectively describe the extent of impaired consciousness in all types of acute medical and trauma patients. The scale assesses patients according to three main aspects of responsiveness: eye-opening, motor, and verbal responses. Reporting each of these separately provides a clear and communicable picture of a patient's state. STATEMENT OF THE PROBLEM A comparative study to assess the effectiveness of demonstration method versus self instructional module on knowledge regarding Glasgow coma scale among 2nd semester B.Sc. Nursing students at selected nursing colleges of city. OBJECTIVES OF THE STUDY- 1.To assess the knowledge regarding Glasgow coma scale among 2nd semester B.Sc. Nursing students at selected nursing colleges of city. 2.To assess the effectiveness of demonstration method on knowledge regarding Glasgow coma scale among 2nd semester B.Sc. Nursing students at selected nursing colleges of city. 3.To assess the effectiveness of self instructional module on knowledge regarding Glasgow coma scale among 2nd semester B.Sc. Nursing students at selected nursing colleges of city. 4.To compare the effectiveness of demonstration Method vs. self instructional module on knowledge regarding Glasgow coma scale among 2nd semester B.Sc. Nursing students at selected nursing colleges of city. 5.To associate pre test knowledge score regarding Glasgow coma scale among 2nd semester B.Sc. Nursing students at selected nursing colleges of city with selected demographic variable. HYPOTHESIS-H0: There will be no significant difference between pre-test and post-test score of demonstration on knowledge regarding Glasgow coma scale among 2nd semester B. Sc nursing students. H01: There will be no significant difference between pre-test and post-test score of self instructional module on knowledge regarding Glasgow coma scale among 2nd semester B. Sc nursing students. H02:There will be n o significancedifferencebetweendemonstrationmethodand self instructional module on knowledge regarding Glasgow coma scale among 2nd semester B. Sc nursing students. H03: There will be no significant association between pre-test levels of knowledge with selected demographic variable. METHODOLOGY A True experimental research design was undertaken to compare the effectiveness of self instructional module vs demonstration method on knowledge regarding Glasgow coma scale among nursing students. The study was conducted among 2nd semester BSc nursing students at College of Nursing, 172 nursing students were selected by using purposive random sampling technique i.e.86ineachgroup.Pre-test was conducted to assess the knowledge on GCS using self administered questionnaire. Then the two groups were given interventions respectively. On the 8th day, post test was conducted for both groups. The data was analyzed for frequency, percentage, mean and standard deviation. Paired t test was done for finding out the effectiveness of the interventions. Independent t test was done to compare both the interventions. RESULTS OF THE STUDY The result of analysis of data shows that in group-I the pre-test mean was 7.47, post test 10.79 with a the standard deviation of 2.69 and 1.65 respectively. In group-2the pre-test was 8.45 post-test was 13.76 with the standard deviation of 2.62 and 2.55 respectively .The mean difference in pre-test was 0.98 and post test was 2.97 with 't' value 1.600 and - 6.037respectively. There was statistical significant difference between the mean knowledge level of demonstration method and self instructional module in post test at p.