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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ITRACONAZOL LOADED SOLID LIPID NANOPARTICLES TO IMPROVE ANTIFUNGAL EFFICIENCY
Authors
Payal B. Rathod,Prof. Swapnil S. Kawarkhe,Dr. Swati P. Deshmukh,Vishal D. Rathod,Ankita D. Haral
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Keywords
Itraconazole, SLN, Fungal infections, High shear homogenization, Ultrasonication, Emulsion.
Abstract
Fungal infections pose a growing threat to human health and livelihood. Tinea capitis are the species of Dermatophytes group of fungi, which cause the fungal infection in the scalp known as scalp ringworm. Solid-lipid nanoparticles (SLNs) are an innovative group of nanosystems used to deliver medicine to their respective targets with better efficiency and bioavailability in contrast to classical formulations. SLNs are less noxious, have fewer adverse effects, have more biocompatibility, and have easy biodegradability. Lipophilic, hydrophilic and hydrophobic drugs can be loaded into SLNs, to enhance their physical and chemical stability in critical environments.
Nanoparticles have many properties that would make them useful antimycotic agents. Nanoparticles can facilitate efficient topical drug delivery by increased penetration, enhanced safety, efficacy and sustained and target release of the drug. Itraconazole a antifungal drug was formulated into drug delivery system aiming to treat opportunistics ringworm infection ( Tinea capitis) that infect scalp.SLN increase the approach to enhance the permeability of Itraconazol through the skin. The used of Itraconazol loaded solid lipid nanoparticles considered a good alternative to control pathogenic fungi in humans. Different synthesis methods have been used to produce the SLNs, few of them are microemulsion dispersion method, homogenization, ultrasonication, melt emulsion sonication, and low temperature solidification method.
Characterization of SLNs includes particle size, zeta potential, drug loading and drug entrapment efficiency.
The objective of the review to evaluate Itraconazol loaded solid lipid nanoparticles to improve the therapeutic efficacy and reduction of toxicity of this broad spectrum antifungal agent. Entrapment efficiency of drug carrier and it's effect in physical parameter, drug release are reviewed. Important points in characterization and stability of SLNs are outlined. The study of the SLNs loaded with Itraconazol was the aim of these investigation. The drug molecules physiochemical and pharmacokinetic performance is constrained by the drug profile, poor solubility, toxicity, instability, incompatibility and poor penetration. The review submerizes the
basic of nanoparticles ( SLN) with respect to drug delivery for better therapeutic effects of scalp ringworm infection.
IJCRT's Publication Details
Unique Identification Number - IJCRT2312285
Paper ID - 245436
Author type - Indian Author
Page Number(s) - c482-c491
Pubished in - Volume 11 | Issue 12 | December 2023
DOI (Digital Object Identifier) -
No Of Downloads - 58
Author Country - India, -, -, -, -, Science and Technology
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
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Payal B. Rathod,Prof. Swapnil S. Kawarkhe,Dr. Swati P. Deshmukh,Vishal D. Rathod,Ankita D. Haral, "ITRACONAZOL LOADED SOLID LIPID NANOPARTICLES TO IMPROVE ANTIFUNGAL EFFICIENCY", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 12, pp.c482-c491, December 2023, Available at :http://www.ijcrt.org/papers/IJCRT2312285.pdf
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