Journal IJCRT UGC-CARE, UGCCARE( ISSN: 2320-2882 ) | UGC Approved Journal | UGC Journal | UGC CARE Journal | UGC-CARE list, New UGC-CARE Reference List, UGC CARE Journals, International Peer Reviewed Journal and Refereed Journal, ugc approved journal, UGC CARE, UGC CARE list, UGC CARE list of Journal, UGCCARE, care journal list, UGC-CARE list, New UGC-CARE Reference List, New ugc care journal list, Research Journal, Research Journal Publication, Research Paper, Low cost research journal, Free of cost paper publication in Research Journal, High impact factor journal, Journal, Research paper journal, UGC CARE journal, UGC CARE Journals, ugc care list of journal, ugc approved list, ugc approved list of journal, Follow ugc approved journal, UGC CARE Journal, ugc approved list of journal, ugc care journal, UGC CARE list, UGC-CARE, care journal, UGC-CARE list, Journal publication, ISSN approved, Research journal, research paper, research paper publication, research journal publication, high impact factor, free publication, index journal, publish paper, publish Research paper, low cost publication, ugc approved journal, UGC CARE, ugc approved list of journal, ugc care journal, UGC CARE list, UGCCARE, care journal, UGC-CARE list, New UGC-CARE Reference List, UGC CARE Journals, ugc care list of journal, ugc care list 2020, ugc care approved journal, ugc care list 2020, new ugc approved journal in 2020, ugc care list 2021, ugc approved journal in 2021, Scopus, web of Science.
How start New Journal & software Book & Thesis Publications
Submit Your Paper
Login to Author Home
Communication Guidelines

WhatsApp Contact
Click Here

  Published Paper Details:

ugc approved journal, UGC CARE Journal, ugc approved list of journal, ugc care journal, UGC CARE list, UGC-CARE, care journal, UGC-CARE list, Journal publication, ISSN approved, Research journal, research paper, research paper publication

  Authors

Dr.D.Ravi sankara Reddy,T.Srinivasarao

  Keywords

Fluconazole, molecular docking, Candida albicans, Variconazole, Anti-fungal drugs

  Abstract


Candidiasis is a common infection of skin, oral, cavity, esophagus, gastrointestinal tract, vagina and vascular systems of humans. The ability of this highly adaptable fungal species to transition from commensal to pathogen is due to a repertoire of virulence factors. Specifically, the ability to switch morphology and form biofilms are properties central to Candida albicans pathogenesis. In past two decades, it has been observed abnormal overgrowth in the gastrointestinal, urinary and respiratory tracts, not only in immunocompromised patients, but also related to nosocomial infections and even in healthy individuals. There are wide variety of causal factors that contribute to yeast infections which means candidiasis is a good example of multifactorial syndrome. This disease transition in the pathophysiology of the onset and progression of infection is also influenced by Candida's virulence traits that lead to the development of candidiasis the disease candidiasis is treated with the drug Fluconazole. In this project I had taken fluconazole as a drug with 10 different similar analogues and 1ea1A as my target protein. Then docking is done at the active site site of the protein by using autodock 1.5.7 version. Then after docking ligands with different binding energies were found out. At the end of this work . I have been screened out one of the analog is with highest binding energy bases on all other binding energy parameters. Finally ligand with PUBCHEM CID-129829800 has highest binding affinity with 8.1kcal/mol among al other similar analogs of Fluconazole

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2309569

  Paper ID - 244422

  Author type - Indian Author

  Page Number(s) - e702-e725

  Pubished in - Volume 11 | Issue 9 | September 2023

  DOI (Digital Object Identifier) -   

  No Of Downloads - 92

  Author Country - India, 522601, Guntur, Guntur, 522601, Chemistry All

  Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT2309569

  Published Paper URL: : - http://ijcrt.org/viewfull.php?&p_id=IJCRT2309569

  Published Paper PDF Downlaod: - download.php?file=IJCRT2309569

  Cite this article

Dr.D.Ravi sankara Reddy,T.Srinivasarao,   "A Molecular Docking Comparison of Fluconazole Drug and its Derivatives for Candida albicans", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 9, pp.e702-e725, September 2023, Available at :http://www.ijcrt.org/papers/IJCRT2309569.pdf

  Share this article

  Article Preview

  Types of Articles invited

Research Papers, Survey Papers, Study Papers, Subjective Papers, Experimental Result Papers, Analysis Study Research Papers, Informative Article, Comparison Papers, Case Studies Papers, Review Papers, Comparative Studies, Dissertation Chapters, Research Proposals or Synopsis, Working Projects, New Innovation & Idea, Prototypes and Models and many More

  Call For Paper

  About IJCRT (Refereed Journal, Peer Journal and Indexed Journal )

About IJCRT

The International Journal of Creative Research Thoughts (IJCRT) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world.

IJCRT is Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 7.97 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool), Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

The open access supports the rights of users to read, download, copy, distribute, print, search, or link to the full texts of these articles provided they are properly acknowledged and cited.


Indexing In Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar | AI-Powered Research Tool, Microsoft Academic, Academia.edu, arXiv.org, Research Gate, CiteSeerX, ResearcherID Thomson Reuters, Mendeley : reference manager, DocStoc, ISSUU, Scribd, and many more

International Journal of Creative Research Thoughts (IJCRT)
ISSN: 2320-2882 | Impact Factor: 7.97 | Impact Factor: 7.97 and Monthly-Peer-reviewed, and Refereed Journals.
Open Access Processing Charges or Publication fees with free DOI : ₹1500 INR for Indian author & 55$ for foreign International author.

Refereed Journal, Peer Journal and Indexed Journal
Publication Issue Frequency : Monthly (12 issue Per Year Annually)
Journal Discipline and Subject : Multidisciplinary,Monthly,Multilanguage (Regional language supported) .
Publisher and Managed By : IJPUBLICATION (ijpublication.org).
Publication Supported Languages: Allow All Multiple Languages (Regional language supported).


Provide DOI and Hard copy of Certificate.
High impact factor and 50+ index database and Fast paper publication.
Nominal Fee for Professional Research Services, Low cost research journal.
Publication Guidelines : COPE Guidelines
Quick, Fast, automatic Speedy Review and publication Process
Notification of Review Result and publication - Within 02-03 Days.
Provide Free e-certificate to all author and DOI (Digital Object Identifiers) to All Paper.
Download all digital data from website anytime lifetime available.
Indexing of paper in all major online journal databases.

Low Publication Charge 1500 INR per single paper Publication with Maximum 5 Author for indian author & 55$ for foreign International author.

Paper Submission Till : 29 June 2024
Review Results (Acceptance/Rejection) Notification : Within 02-03 Days
Paper Publication Time : Paper Publish: Within 02-03 Days after submitting all the required documents.

Submit your Paper Submit your paper


Call For Paper (Volume 12 | Issue 6 | Month- June 2024)

Licence and Indexing

Indexing In Google Scholar, ResearcherID Thomson Reuters, Mendeley : reference manager, Academia.edu, arXiv.org, Research Gate, CiteSeerX, DocStoc, ISSUU, Scribd, and many more | High Impact Factor: 7.97 | Digital object identifier (DOI) and Hard Copy of certificate Provided.







Licence

DOIIJCRT Research Journal
ISSN Approved
Impact Factor: 7.97 IJCRT Research Journal
Creative Common IJCRT Research Journal
Valid as per new UGC Gazette regulations IJCRT Research Journal

Features

Impact Factor: 7.97 and ISSN approved.
Impact Factor: 7.97 Calculated by google scholar
Call For Paper (Volume 12 | Issue 6 | Month- June 2024)
Quick, Fast, automatic Speedy Review Process
Notification of Review Result - Within 02-03 Days.
Publication of Paper - Within 02-03 Days.

Provide Free DOI(Digital Object Identifiers) to All Paper.
Provide Hard copy of certificate based on request.
Indexing of paper in all major online journal databases.
SEO effective and Automated Metadata Citation Generator.

Open-Access peer reviewed International Journal
Fully Automated and Secure https Website
Author can Check Publication Process status online.
EMail and SMS notification to the author for each Process stage.
Paper and Soft Copy of "Certificate" Available life time on website.

Qualifed & Experience Reviewers from Well-known Institutes/Universities among the world.
Social Media, Email and Call Support 24*7.
Google Scholar, ResearcherID Thomson Reuters Indexing.
Author Research Guidelines & Support.

  Indexing Partners

indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
Call For Paper June 2024
Indexing Partner
ISSN and 7.97 Impact Factor Details


ISSN
ISSN
ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
ISSN
ISSN and 7.97 Impact Factor Details


ISSN
ISSN
ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
ISSN
DOI Details

Providing A Free digital object identifier by DOI.one How to get DOI?
For Reviewer /Referral (RMS) Earn 500 per paper
Our Social Link
Open Access
This material is Open Knowledge
This material is Open Data
This material is Open Content
Indexing Partner

Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 7.97 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer
indexer