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Effect Of Shatavari ghrita (Polyherbal Formulation) On Testicular Dysfunction In Streptozocin Induced Diabetes In Wistar Albino Rats
Authors
Nishvanth F,Sakthi Abirami M
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Keywords
Shatavari ghrita, Diabetes mellitus, Testicular dysfunction, Streptozocin, Mucuna pruriens
Abstract
Shatavari ghrita is a herbal medicine containing Shatavari (Asparagus recemosus) root, milk and ghee in the ratio of 1:4:16. Diabetes mellitus can damage the gonads, leads to spermatogenic cell damage. To evaluate the effect of SG on testicular dysfunction by streptozocin induced diabetes in wistar albino rats. The dose should be selected by acute toxicity study and it has no morbidity and mortality rate so it has been selected that 1/5th dose (400mg/kg) and 1/10th dose (200mg/kg). 30 wistar albino rats were divided into 5 groups (n=6) Group I (control), Group II to IV treated with single dose injection (i.p) of STZ (40mg/kg). After induction of diabetes, Group II has diabetic control, Group III treated with mucuna pruriens chooranam (200mg/kg), group IV treated with SG 200mg/kg and Group V treated with SG 400mg/kg for 60 days. On the day 61, rats were sacrificed, FBG estimated, semen collected from epididymis, serum collected for antioxidant enzymes and MDA level and histopathological examination. All the data were analysed by one way ANOVA followed by Dunnett's test. In SG 400mg/kg, there was increased in sperm count, motility and viability, increased reproductive organ weight, increased serum testosterone level and anti-oxidant activity, decreased the level of MDA and blood glucose level.Present findings provide experimental in-vitro and in-vivo evidence that the Shatavari ghrita reversed by the diabetes induced testicular dysfunction. Phytochemicals present in SG possess anti-hyperglycemic and anti-oxidant properties.
IJCRT's Publication Details
Unique Identification Number - IJCRT2308237
Paper ID - 242352
Author type - Indian Author
Page Number(s) - c140-c146
Pubished in - Volume 11 | Issue 8 | August 2023
DOI (Digital Object Identifier) -
No Of Downloads - 112
Author Country - India, 627651, Tirunelveli Dt, Tirunelveli Dt, 627651, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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Nishvanth F,Sakthi Abirami M, "Effect Of Shatavari ghrita (Polyherbal Formulation) On Testicular Dysfunction In Streptozocin Induced Diabetes In Wistar Albino Rats", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 8, pp.c140-c146, August 2023, Available at :http://www.ijcrt.org/papers/IJCRT2308237.pdf
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