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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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Authors
Dr Vamseekrishna G
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Keywords
Discosomes, Disc-shaped, Vesicular, Ophthalmic
Abstract
The Pharmaceutical formulation is employed to propagate pharmaceutical drug compound in the body to obtain the therapeutic effect at a predetermined rate depending on pharmacological aspects, drug profile, and physiological conditions can be referred to as a novel drug delivery system. Due to the sensitive anatomy and physiology of the eye pharmacologist find the ocular delivery system to be more complicated than other routes. Pre-corneal, static and dynamic is the 3 types of ophthalmic barriers, which along with the inflow and outflow of lacrimal fluids, nasolacrimal drainage, are some of the prime factors that affect bioavailability. Unlike conventional dosage forms, where the distribution of drugs in non-targeted body fluids and tissues transcends the quantity of required drug in targeted tissues and causes repercussions, these modified drug delivery systems overcome the ocular barriers and adverse reactions, emphasizing on less invasive, prolonged action. It also promotes sustained release formulation that subjugates the drug loss or degradation to treat many ocular diseases effectively. The current review focus on the fundamentals of discosomes, a type of vesicular drug delivery system that acts as a vehicle for the drug delivery of both hydrophilic and lipophilic drugs. Discosomes are giant, disc-shaped structures modified from niosomes by arresting the vesicles at the discosome phase. Due to their peculiar size, it offers all due benefits compared to other ocular drug delivery systems. From the review, it can be concluded that discosomes are a key subject of opportunities in the domain of safe and effective ocular drug delivery.
IJCRT's Publication Details
Unique Identification Number - IJCRT2307820
Paper ID - 241750
Author type - Indian Author
Page Number(s) - g961-g976
Pubished in - Volume 11 | Issue 7 | July 2023
DOI (Digital Object Identifier) -
No Of Downloads - 107
Author Country - India, -, -, -, -, Science and Technology
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT2307820
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Dr Vamseekrishna G, "Discosomes - A Vesicular Drug Delivery System", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 7, pp.g961-g976, July 2023, Available at :http://www.ijcrt.org/papers/IJCRT2307820.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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