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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Published Paper Details:
"Formulation And Evaluation Of Metformin mouth dissolving film by using flaxseed extract."
Authors
Rajendra Kharade,Anant More,Tushar Garje,Pratiksha Gawade,Ajay More
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Keywords
Mouth dissolving film, Permeability, Bioavailability, Salivary fluid, Solvent casting method, HPMC
Abstract
The seed of a multipurpose plant of pharmacological interest is flaxseed (Linum usitatissimum L.), whose mucilage can be utilized as a natural matrix to create dosage forms with longer release and possibly replace synthetic polymers.The high concentration of ?-linolenic acid (ALA, omega-3 fatty acid), lignans, and fiber found in flaxseed is making it a popular addition in functional foods.Flaxseed may enhance the blood sugar-lowering benefits of several diabetes medications and may also lower blood sugar levels, according to some research. Blood sugar levels falling too low is a worry. Pay special attention to your blood sugar levels if you use flaxseed and have diabetes.According to some, it's among the planet's most potent plant-based foods. Using a cheap, naturally occurring flax seed polymer that is safe for use in fast-dissolving films is the goal of this work. The concept of Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules etc.This work investigated the possibility of developing rapid dissolving films allowing fast, reproducible drug dissolution in the oral cavity. Fast mouth dissolving thin film is a solid dosage form, which disintegrate or dissolve within 1 min when placed in the mouth without drinking of water or chewing. Oral film includes various ingredients for its formulation which includes polymers, active pharmaceutical ingredient, sweeteners, saliva stimulating agents, disintegration agent, plasticizer etc . but the first and far most a very essential ingredient which helps in film formation is a Polymer. Fast dissolving Film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made. Water-soluble polymers are used as film formers for fast dissolving films. Our current work is designed to manufacture oral thin films (the mouth dissolving film of domperidone) using the solvent casting method, taking into consideration the aforementioned factors. Using this procedure, an aqueous solution was created by dissolving HPMC in 25 milliliters of distilled water, and it was left for an hour to eliminate any trapped air bubbles. Afterwards, the mixed solution was placed on a petri dish and allowed to dry for a whole day at room temperature. Once the film had dried, it was carefully taken out of the petri dish, sliced into 2x2 sq cm strips, and stored in a desiccator. A innovative strategy to increasing consumer acceptance is the use of oral thin films of domperidone, which have several advantages such as quick disintegration, water-free self-administration, a high percentage of the drug, and a long mucoadhesion time.
IJCRT's Publication Details
Unique Identification Number - IJCRT21X0232
Paper ID - 260624
Author type - Indian Author
Page Number(s) - m767-m798
Pubished in - Volume 12 | Issue 5 | May 2024
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No Of Downloads - 24
Author Country - India, -, -, -, -, Science and Technology
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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Rajendra Kharade,Anant More,Tushar Garje,Pratiksha Gawade,Ajay More, ""Formulation And Evaluation Of Metformin mouth dissolving film by using flaxseed extract."", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.12, Issue 5, pp.m767-m798, May 2024, Available at :http://www.ijcrt.org/papers/IJCRT21X0232.pdf
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The International Journal of Creative Research Thoughts (IJCRT) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies.
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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