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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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SOLUBILITY ENHANCEMENT OF ITRACONAZOLE BY SELF-EMUSIFYING DRUG DELIVERY SYSTEM
Authors
Shrishail M Ghurghure,Priya L. Ingale
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Keywords
Self-Nanoemulsifying Drug Delivery, System, Poorly Water Soluble drugs,Oral Bioavailability,Itraconazole,Surfactant, Co-surfactant,Poor Bioavailability
Abstract
Oral route is the most convenient route for drug administration. More than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. Improving oral bioavailability of low poorly water soluble drugs using Self Nano emulsifying Drug Delivery System (SNEDDS) possess significant potential.
The nanoemulsion was characterised by measuring Transmission Electron Microscopy, Particle Size distribution Analysis, Zeta Potential Analysis.
To optimize formulation of SNEDDS is a potential alternative oral dosage form for improving oral absorption of Itraconazole.
SNEDDS formulation has significantly increased the absorption rate when compared to the pure drug. Thus, this SNEDDS should be an effective oral dosage form for improving oral bioavailability of lipophilic drug Itraconazole. The Lipid-based drug delivery system is extensively reported within the literature for enhancing drug solubility, permeability, and bioavailability. A considerable majority of novel pharmacologically active constituents produced in recent drug discovery programs are lipophilic and poorly soluble, posing a significant problem for pharmaceutical researchers enhancing the oral bioavailability of such drug molecules. Self-Nanoemulsifying Drug Delivery Systems (SNEDDS), are the viable oil-based approaches for drugs that exhibit low dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, researchers have been focusing on the challenges of BCS Class II and Class IV Drugs for enhancing water Solubility of poorly water-soluble drugs. SNEDDS is a Validate method for enhancing the solubility and bioavailability of lipophilic compounds. It's the isotropic mixture of oil, surfactant, co-surfactant molecules and it also contains co-solvent molecules. Which spontaneously form oil-in-water nano emulsion of approximately 200 nm or less in size upon dilution with water under gentle stirring. Its Drug delivery system which possesses thermodynamically and kinetically stability. The physicochemical properties, drug solubilisation capacity considerably regulate the selection of the SNEDDS components. The compositions of the SNEDDS are often optimized with the assistance of phase diagrams. Further optimization of SNEDDS can be done with the help of statistical experimental design.
IJCRT's Publication Details
Unique Identification Number - IJCRT2305626
Paper ID - 237071
Author type - Indian Author
Page Number(s) - f181-f188
Pubished in - Volume 11 | Issue 5 | May 2023
DOI (Digital Object Identifier) -
No Of Downloads - 85
Author Country - India, 413002, Solapur, Solapur, 413002, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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Shrishail M Ghurghure,Priya L. Ingale, "SOLUBILITY ENHANCEMENT OF ITRACONAZOLE BY SELF-EMUSIFYING DRUG DELIVERY SYSTEM", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 5, pp.f181-f188, May 2023, Available at :http://www.ijcrt.org/papers/IJCRT2305626.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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