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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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Published Paper Details:
STUDY OF GENETIC VARIATIONS IN par C GENE IN QUINOLONE RESISTANT ISOLATES OF Escheria coli FROM URINARY TRACT INFECTIONS
Authors
DINICHANDRAN C S,Dr.Mangayarkarasi,Dr.Parani
Downlaod Center
Keywords
Urinary tract infections,antibiotic resistance,endothelial cells
Abstract
Abstract: Urinary tract infection (UTI) is a bacterial infection that affects any part
of the urinary tract. When bacteria get into the bladder or kidney and multiply in the urine, they
cause a UTI. The most common type of UTI is a bladder infection which is also called cystitis.
Another kind of UTI is a kidney infection, known as pyelonephritis, and is much more serious.
The diagnosis of UTI is confirmed by a urine culture. Uropathogenic Escheria coli (UPEC) is
responsible for approximately 90% of UTI seen in individuals with ordinary anatomy.
Uropathogenic Escheria coli utilize Pfimbriae (pyelonephritis -associated pili)to bind urinary
tract endothelial cells and colonize the bladder. These adhesins specifically bind D-galactose-D-
galactose moieties on the P blood group antigen of erythrocytes and uroepithelial cells.
Approximately 1% of the human population lacks this receptor,and its presence or absence
dictates an individual's susceptibility to Escheria coli urinary tract infections. UPEC can evade
the body's innate immune defence, the complement system by invading superficial cells to form
intracellular bacterial communities(IBCs).IBCs have the ability to form K antigen, capsular
polysaccharides that contributes to biofilm formation. Biofilm producing Escheria coli are
recalcitrant to immune factors and antibiotic therapy and are often responsible for chronic
urinary tract infections. Quinolones are a family of broad spectrum antibiotics. They inhibits the
bacterial DNA gyrase or topoisomerase IV enzyme thereby inhibiting DNA replication and
transcription. The present study reveals the prevalence rate of quinolone resistant isolates of
Escheria coli from patients suffering from UTI attending in SRM Medical college hospital and
Research Centre, Chennai.
IJCRT's Publication Details
Unique Identification Number - IJCRT2305555
Paper ID - 236973
Author type - Indian Author
Page Number(s) - e392-e399
Pubished in - Volume 11 | Issue 5 | May 2023
DOI (Digital Object Identifier) -
No Of Downloads - 81
Author Country - India, 691001, MUNDAKKAL (EAST), MUNDAKKAL (EAST), 691001, Life Sciences All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
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DINICHANDRAN C S,Dr.Mangayarkarasi,Dr.Parani, "STUDY OF GENETIC VARIATIONS IN par C GENE IN QUINOLONE RESISTANT ISOLATES OF Escheria coli FROM URINARY TRACT INFECTIONS", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 5, pp.e392-e399, May 2023, Available at :http://www.ijcrt.org/papers/IJCRT2305555.pdf
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