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A COMPREHENSIVE REVIEW ON MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM
Authors
R. HEMALATHA
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Keywords
Buccal drug delivery system, Mucoadhesive drug delivery system, Mucoadhesion, mucoadhesive polymers, Permeation enhancers, Bioadhesive polymers
Abstract
The use of mucoadhesive drug delivery systems is a promising innovation in the field of pharmaceuticals. Mucoadhesive drug delivery systems are particularly relevant for getting local and systemic drugs distribution in the Gastro Intestinal Tract (GIT) for a prolonged period of time at a predetermined rate. This is in contrast to oral controlled release drug delivery systems, which are often subject to extensive presystemic metabolism and degradation in the acidic environment of the stomach, resulting in insufficient absorption of the drugs. One of the advantages of mucoadhesive drug delivery systems is that they allow for direct passage of medication into the systemic circulation through the buccal mucosa, which is the lining of the mouth. This results in easy administration without pain, brief enzymatic activity, less hepatic metabolism, and higher bioavailability of the drug. Additionally, mucoadhesive drug delivery systems do not require extensive patient compliance or supervision, as is often the case with parental drug delivery systems.The mechanism of mucoadhesion involves the interaction between the mucoadhesive polymer and the mucus layer of the mucosal surface. Mucoadhesive polymers are designed to adhere to the mucosal surface and remain in place for an extended period of time, allowing for a sustained release of the drug. In-vitro and in-vivo mucoadhesion testing techniques are used to evaluate the efficacy of the mucoadhesive drug delivery system.In summary, mucoadhesive drug delivery systems offer several advantages over traditional oral controlled release and parental drug delivery systems, including higher bioavailability of the drug, ease of administration, and sustained release. Further research is needed to optimize the design of mucoadhesive drug delivery systems and to fully understand their potential in the field of pharmaceuticals.
IJCRT's Publication Details
Unique Identification Number - IJCRT2303241
Paper ID - 232353
Author type - Indian Author
Page Number(s) - c220-c229
Pubished in - Volume 11 | Issue 3 | March 2023
DOI (Digital Object Identifier) -
No Of Downloads - 114
Author Country - India, 506009, Hanamkonda, Hanamkonda, 506009, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT2303241
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R. HEMALATHA, "A COMPREHENSIVE REVIEW ON MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 3, pp.c220-c229, March 2023, Available at :http://www.ijcrt.org/papers/IJCRT2303241.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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