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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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FORMULATION AND EVALUATION OF BI-LAYER SUSTAINED RELEASE TABLET OF AZITHROMYCIN AND DOXYCYCLINE DRUG IN COVID-19 TREATMENT
Authors
Rameshwar Baban katkhade,Prof.N.S Mhaske
Downlaod Center
Keywords
Bi-layer tablet, Sustained release tablet, Azithromycin, Covid-19, Doxycycline, SARS-CoV-2, Omicron, Nongonococcal urethritis, Epidemic, Delta.
Abstract
SARS-CoV-2, a novel corona virus, has caused an outbreak of COVID-19, a highly infectious pandemic that has complex viral pneumonia. Patients with risk factors are more likely to acquire secondary infections, which necessitate the use of antibiotics. However, drug repurposing initiatives have led to the recognition of antibiotics' roles outside of infection treatment. The current study looked at two medicines, azithromycin and doxycycline, and their antiviral, immunomodulatory, and distinctive pharmacokinetic profiles. It summarises current clinical trials as well as concerns about these medications' safety. Azithromycin has good lung tissue penetration, wide antibacterial action, and antiviral potential against COVID-19. It also demonstrated benefit when combined with other antiviral drugs in limited clinical studies, however many physicians are concerned about cardiovascular risk in sensitive individuals. Doxycycline is an essential antibiotic used to treat pneumonia. It has several benefits, including cardiac safety, simple access to lung tissue, antiviral potential, and immunomodulation effects via several channels. The pharmacological properties of these drugs suggest that more investigation into their usage in the treatment of COVID-19 is possible. The COVID-19 illness, which has no known cures or therapies, has wreaked devastation on mankind and gone beyond and beyond what has ever been seen before. The review discusses the possible therapeutic applications of Doxycycline in COVID-19 treatment, as well as the potential negative repercussions of repurposing the antibiotic in terms of antimicrobial resistance. Background Because of its antibacterial, anti-inflammatory, and antiviral properties, azithromycin could be utilised to treat COVID19. In mild-to-moderate disease, there are no randomization data. We wanted to see if azithromycin may help persons who had mild-to-moderate infections avoid being admitted to the hospital. COVID-19. Covid is a young man of 19 years. More factors will emerge as the illness worsens day after day. Corid-19 is 100% pure. One does not exist. Researchers nowadays may be found all around the globe. A global outbreak was proclaimed by the World Health Organization in 2020. are making an effort To some degree, this combination can be used as a solution for (AZI) and (DOXY).
IJCRT's Publication Details
Unique Identification Number - IJCRT22A6761
Paper ID - 222203
Author type - Indian Author
Page Number(s) - g196-g223
Pubished in - Volume 10 | Issue 6 | June 2022
DOI (Digital Object Identifier) -
No Of Downloads - 438
Author Country - India, 413249, SHIRUR KASAR BEED, SHIRUR KASAR BEED, 413249, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
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Rameshwar Baban katkhade,Prof.N.S Mhaske, "FORMULATION AND EVALUATION OF BI-LAYER SUSTAINED RELEASE TABLET OF AZITHROMYCIN AND DOXYCYCLINE DRUG IN COVID-19 TREATMENT", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 6, pp.g196-g223, June 2022, Available at :http://www.ijcrt.org/papers/IJCRT22A6761.pdf
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The International Journal of Creative Research Thoughts (IJCRT) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies.
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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