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  Authors

Nandam Hemalatha,Katteboina Venkata Sai Padmini,Gurram.Sindhu Sravanthi,Shaik. Allavuddin

  Keywords

Bioadhesion, mucoadhesion, van-der-waal force, consolidation stage.

  Abstract


Mucoadhesive drug system interact with the mucus layer covering the mucosal epithelial surface, mucin molecular and increase the residence time of the dosage form at the site of absorption. Mucosal adhesion is backed by several theories which include electronic, absorption, wetting, diffusion, fracture and mechanical. Stages of mucoadhesion include contact stage and consolidation stage. Mucoadhesion while considering drug delivery is having several merits, because of the ideal physiochemical characters of the mucosal membrane by ionic bonds, covalent bonds, van-der-waal bonds and hydrogen bond. Various sites for mucoadhesive drug delivery system are ocular, nasal, buccal cavity; GIT, vaginal, rectal and several specific dosage forms have been reported. Factors affecting mucoadhesion are , presence of carboxylate group and density. several synthetic and natural polymers are identified assuitable candidates for mucoadhesive formulation. EX-vivo/in-vitro studies utilizing gut sac of rate provides indepth knowledge about the adhesive property of the dosage form as well as polymers.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2203162

  Paper ID - 216776

  Author type - Indian Author

  Page Number(s) - b369-b380

  Pubished in - Volume 10 | Issue 3 | March 2022

  DOI (Digital Object Identifier) -   

  No Of Downloads - 329

  Author Country - India, 522601, Narsaraopeta, Narsaraopeta, 522601, Pharmacy All

  Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT2203162

  Published Paper URL: : - http://ijcrt.org/viewfull.php?&p_id=IJCRT2203162

  Published Paper PDF Downlaod: - download.php?file=IJCRT2203162

  Cite this article

Nandam Hemalatha,Katteboina Venkata Sai Padmini,Gurram.Sindhu Sravanthi,Shaik. Allavuddin,   "MUCOADHESIVE DRUG DELIVERY SYSTEM", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 3, pp.b369-b380, March 2022, Available at :http://www.ijcrt.org/papers/IJCRT2203162.pdf

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