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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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DIFFERENCES IN EXPRESSION OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) ACCORDING TO SUBTYPES OF BREAST CANCER IN VERY YOUNG WOMEN IN RSUP H. ADAM MALIK MEDAN
Authors
Rafki Hidayat,Kamal Basri Siregar,Suyatno
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Keywords
Keywords: IGF1R, subtype, breast cancer
Abstract
ABSTRACT
Background: Breast cancer is the most common cancer in women (24.2%) and the second most common cancer in the world (11.6%). Approximately 2.089 million new cases of breast cancer were identified in 2018. Expression of IGF-1R correlates with ER expression and predicts a favorable phenotype. Several studies have confirmed further cross-talk between ER and IGF-1R in breast cancer.
Objective: The purpose of this study was to determine differences in IGF1R expression according to breast cancer subtypes in very young women at H. Adam Malik General Hospital Medan.
Methods: This study was an observational analytic study using a cross-sectional design. The sample in this study was a woman with a diagnosis of breast cancer at a very young age at RSUP H. Adam Malik Medan from January 2015 to December 2019 who met the inclusion and exclusion criteria of 52 samples.
Results: In this study, the median age of patients in luminal A breast cancer subtype was 33 years, where the age of the youngest patient was 23 years and the age of the oldest patient was 35 years. It was found that 33 patients (63.5%) had low IGF1R expression and 19 patients (36.5%) and 20 patients (38.5%) with an advanced local stage and only 1 patient (1.9%) with an early stage. In the test of significant differences in IGF1R expression according to breast cancer subtypes in very young women at H. Adam Malik General Hospital Medan with a p-value of 0.031 (p <0.05).
Conclusion: There is a significant difference in IGF1R expression according to breast cancer subtype in very young women at RSUP H. Adam Malik Medan where higher expression was found in luminal A compared to luminal B and TNBC.
IJCRT's Publication Details
Unique Identification Number - IJCRT2102260
Paper ID - 203269
Author type - Foreign Author
Page Number(s) - 2104-2113
Pubished in - Volume 9 | Issue 2 | February 2021
DOI (Digital Object Identifier) -
No Of Downloads - 1214
Author Country - Indonesia, 20154., Medan, Medan, 20154., Humanities All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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Rafki Hidayat,Kamal Basri Siregar,Suyatno, "DIFFERENCES IN EXPRESSION OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) ACCORDING TO SUBTYPES OF BREAST CANCER IN VERY YOUNG WOMEN IN RSUP H. ADAM MALIK MEDAN", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 2, pp.2104-2113, February 2021, Available at :http://www.ijcrt.org/papers/IJCRT2102260.pdf
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