Published Paper Details:

Whole world is fighting against single enemy, novel corona virus (nCoV) causing respiratory trouble, the disease originated from Wuhan of China at the end of 2019 (COVID-19) which is very much similar with the corona virus causing severe acute respiratory syndrome, the disease outbrocken in 2003 (SARS). That is why nCoV is also called SARS-CoV-2/2019-nCoV. Present world is exhausted under massive lockdown and becoming looser day by day. No specific treatment yet to be established except repositioning of some old drugs, though they possess risky side effects. At this juncture to overcome adverse side effects of such drugs, aiming to search naturally occuring candidates targetting to establish a treatment model and to combat the challenge. The traditional plants/spices of bitter taste from Indian origin like Azadirachta indica A. Juss. (Indian Lilac/Neem/Nimtree), Andrographis paniculata (Burm. f.) Nees (green chirata/Indian kalmegh), Momordica charantia L. (bitter gourd/bitter melon/Indian karela), Moringa oleifera Lam. (Tree of life/Miracle-/Drumstick-/Horseradish tree), Curcuma longa L. (turmeric/Indian Haridra) rhizome and Nigella sativa L. (Black Cumin/Kalonji/Indian Kalojeera) seeds commonly pose the antimalarial, antidiabetic, antihyperlipidemic, anti-inflammatory/antiarthritic, immunomodulatory, and antiviral bioactive behaviors as therapeutics. Chloroquine/Hydroxychloroquine are resembled the same behaviors concomitantly. Both chloroquine(CQ) and hydroxychloroquine(HCQ) are synthetic antimalarial and antiarthritic drugs but recently repurposing the antiviral activity against SARS-CoV-2. CQ exhibits adverse side effects like vision loss, psychiatric disorder, cramp etc.. But HCQ, hydroxylated derivative of CQ is less toxic than CQ. HCQ on the other hand, it has been linked to some instances of cardiac arrhythmia, macular disorder and liver damage. Present study aiming to evaluate naturally occuring preventive/prophylactic/alternative potentials from Indian perspective searching database from existing literature and internets to overcome such odd side effects of CQ/HCQ on human subjects. The common/signature bioactive behaviors of some Indian traditional bitter plants/spices (SITBP/S) mentioned above and CQ/HCQ are more or less are found to be similar. Moreover SITBP/S exhibits anthelmintic and antiulcer good effects found from literature. Also a di-/tri-/polyherbal formulation could be suggested by constructing a Common base-tetra-triangular (CBTT) model for traditional treatment thus proposed and implimented on a very small group of COVID-19 suspected symptomatic patients from my Instititute at preliminary level, especially as preventive/prophylactic or alternative antiviral approach to SARS-CoV-2, might be rationalized to replace the CQ/HCQ side effective treatment. CBTT model of treatment + azithromycin (AZ) were implimented in presence or absence of antiallergic medications (AAMs) in symptomatic patients those who were denied to go Hospital. Without the AAMs, 7 days delay of recovery was observed. Resulting CBTT model +AZ + AAMs could be repurposed for faster recovery.