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DESIGN AND DEVELOPMENT OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF MELOXICAM
Authors
K Ashok,M.V. Nagabhushanam
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Keywords
Meloxicam, Poloxomer -F338, Gelucire 48/16, spherically agglomeration
Abstract
In the present work an attempt was done to study the effect of different carriers on the solubility and dissolution rate of Meloxicam poorly water soluble COX-2 inhibitor, by spherically agglomeration using methanol, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of Meloxicam were prepared by using Poloxomer -F338 and Gelucire 48/16 in the ratio of 1:0.5,1:0.75,1:1. The agglomerates were subjected to various physicochemical evaluations such as practical yield, drug content, solubility, flow properties, average particle size, scanning electron microscopy and dissolution studies. The optical electron microscopy studies showed that the agglomerates possesses a good spherical shape. This study, demonstrated that the successful development of directly compressible spherical agglomerates of Meloxicam prepared with selected carriers enhances the in-vitro dissolution property of Meloxicam, which could provide rapid onset of action and potentially increases oral bioavailability. To study the influence of co-processed superdisintegrants on performance of Meloxicam Fast dissolving tablets, a set of three formulations (F7, F8, F9) were prepared using co-processed superdisintegrants (Croscarmalose sodium:Crospovidone) in three different ratios 1:1, 1:2, 1:3 respectively. The formulation prepared with co-processed superdisintegrants (Croscarmalose sodium:Crospovidone) in 1:3 ratio (F9) was offered relatively rapid release of Meloxicamwhen compared with other ratios employed in this investigation.
IJCRT's Publication Details
Unique Identification Number - IJCRT1812857
Paper ID - 187717
Author type - Indian Author
Page Number(s) - 1605-1611
Pubished in - Volume 6 | Issue 2 | April-2018
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No Of Downloads - 1152
Author Country - 523001, India, ONGOLE, ONGOLE, India, Pharmacy
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
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K Ashok,M.V. Nagabhushanam , "DESIGN AND DEVELOPMENT OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF MELOXICAM", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.6, Issue 2, pp.1605-1611, April-2018, Available at :http://www.ijcrt.org/papers/IJCRT1812857.pdf
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